In this episode of The Bioactive Nexus podcast, Dr. Bill Clark and Dr. Gene Bruno delve into the critical topic of cognitive function, particularly as it relates to aging and the growingmarket for brain health supplements. They discuss the importance of understanding cognitive function's subdomains, such as memory and attention, and explore the mechanisms of action that underpin various nutraceuticals. The conversation highlights market trends, key ingredients for cognitive support, and the significance of formulation strategies that consider consumer expectations. The episode concludes with insights into future topics, including the role of psychedelics in cognitive health and the importance of gut health for brain function.

Keywords

cognitive function, brain health, nutraceuticals, neuroplasticity, aging, supplements, mechanisms of action, market trends, formulation strategies, consumer expectations

Takeaways

· Cognitive function is crucial as we age.

· Neuroplasticity allows the brain to reorganizeitself.

· The nootropics market is rapidly growing.

· Different mechanisms of action should be used informulations.

· Realistic consumer expectations are essentialfor product success.

· Gut health significantly impacts cognitivefunction.

· Psychedelics are gaining attention in cognitivehealth research.

· Formulation strategies should avoid the kitchensink approach.

· Clinically relevant doses are necessary foreffectiveness.

· Brain health requires a long-term commitment.

Chapters

00:00 Introduction to Cognitive Function and Aging

07:16 Understanding Cognitive Function and Neuroplasticity

12:04 Market Trends in Brain Health Supplements

18:17 Mechanisms of Action in Cognitive Health

20:06 Key Ingredients for Cognitive Enhancement

21:46 Exploring Cognitive Enhancers: Lion's Mane and Ginkgo Biloba

23:21 The Power of Caffeine and Theanine

25:04 Omega-3s and Spermidine: Essential Nutrients for BrainHealth

26:53 Emerging Ingredients: Uridine Monophosphate and PQQ

28:49 The Role of Sage and Nicotinamide Riboside inCognitive Function

30:46 Neuroprotective Polyphenols: Blueberries and Curcumin

32:07 Formulation Strategies: Synergy and Dosing

35:23 Navigating Nootropic Claims: Real vs. Hype

38:56 Building Brand Loyalty Through Realistic Expectations

41:14 Final Takeaways: The Long Game of BrainHealth

In this conversation, experts discuss the implications ofGLP-1 receptor agonists like Ozempic in the context of weight loss and the supplement industry. They explore the mechanisms of GLP-1, the importance of diet and exercise, and the challenges faced by individuals using thesemedications. The panelists emphasize the need for a comprehensive approach to obesity, including dietary changes and physical activity, while also addressingthe role of natural products and emerging research in metabolic health. They conclude with thoughts on the future of weight management and the importance of consumer education in navigating the supplement landscape.

Please see the links below for more information on our guests’ companies.

• Dr. Jacqueline Jacques, ND – Wellness Industry Expert, obesity specialist, vocal critic of “natural Ozempic” claimso https://www.bariatricadvantage.com/o https://www.mvpnutra.net/o https://shop.myeq.com/

• Jim Ayres – CEO of Kelker Pharma, product development and contract manufacturing leadero https://kelkerpharma.com/

• Dr. Luc Maes, ND – Founder of KAIBAE, expert in gut–metabolic axis, polyphenols, and microbiome scienceo https://maescenter.com/o https://www.baobabingredients.com/o https://gokaibae.com/

• Michael Bengivenga – SVP, New Business Development Vitaworks, experienced in brand and commercial development in the supplement spaceo https://vitaworksusa.com/

In this conversation, Dr. Gene Bruno and Dr. Bill Clark explore the twelve hallmarks of aging, discussing how each hallmark impacts health and longevity. They delve into the role of nutraceuticals in addressing these hallmarks, emphasizing the importance of genomic stability, telomere length, epigenetic alterations, and more. The discussion highlights the interconnectedness of these factors and their implications for maintaining health as we age.