This review article explores the potential benefits of creatine supplementation for brain health and function. It summarizes current research showing that creatine can increase brain creatine stores, potentially improving cognition and memory, especially under metabolic stress or in aging adults. The paper also discusses promising effects of creatine in managing symptoms associated with traumatic brain injuries, muscular dystrophies, depression, and anxiety.

Candow DG, Forbes SC, Ostojic SM, et al. "Heads Up" for Creatine Supplementation and its Potential Applications for Brain Health and Function. Sports Med. 2023;53(Suppl 1):49-65.

doi:10.1007/s40279-023-01870-9

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This academic paper from the journal Biology presents research investigating the relationship between strength training frequency and telomere length, a marker of biological aging, in a large, representative sample of U.S. adults.

Tucker LA, Bates CJ. Telomere Length and Biological Aging: The Role of Strength Training in 4814 US Men and Women. Biology (Basel). 2024;13(11):883. doi:10.3390/biology13110883

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This scientific paper explores the phenomenon of neuronal senescence in the dorsal root ganglia (DRG), which are clusters of nerve cells involved in sensory perception. The research demonstrates that aging and peripheral nerve injury both contribute to the accumulation of senescent neurons in the DRG of mice and humans. These senescent neurons are found to express pro-inflammatory markers like IL6 and exhibit altered electrical excitability, particularly in nociceptors, which are pain-sensing neurons. Crucially, the study shows that targeting and removing these senescent cells with a senolytic drug can improve pain-related behaviors, suggesting a potential therapeutic avenue for treating chronic pain, especially in older individuals.

Donovan, L.J., Brewer, C.L., Bond, S.F. et al. Aging and injury drive neuronal senescence in the dorsal root ganglia. Nat Neurosci 28, 985–997 (2025). https://doi.org/10.1038/s41593-025-01954-x

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This research analyzes factors predicting spontaneous regression of lumbar disc herniation (LDH), a common cause of back pain and sciatica. The authors conducted a systematic review and meta-analysis of existing literature, examining various disc morphologies (bulging, protruded, extruded, and sequestered) and other characteristics.

Rashed S, Vassiliou A, Starup-Hansen J, Tsang K. Systematic review and meta-analysis of predictive factors for spontaneous regression in lumbar disc herniation. J Neurosurg Spine. 2023;39(4):471-478. doi:10.3171/2023.6.SPINE23367

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This systematic review and meta-analysis examines the effectiveness of exercise-based injury-prevention programs in team handball players, a sport associated with high injury rates, particularly in the lower extremities and shoulder. The research synthesized data from multiple databases to assess if these programs could reduce the incidence of various injuries.

Naderi A, Shaabani F, Keikha M, Degens H. Is an Exercise-Based Injury-Prevention Program Effective in Team Handball Players? A Systematic Review and Meta-Analysis. J Athl Train. 2024;59(8):845-856. doi:10.4085/1062-6050-0680.22

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