Podcast Episode: Aubrey de Grey on the Science of Immortality & Longevity Escape Velocity

Is human immortality inevitable? According to Aubrey de Grey, one of the world’s leading longevity researchers, the answer is yes—or at least, aging will no longer be what kills us. He believes that by the late 2030s or early 2040s, we will reach Longevity Escape Velocity (LEV)—the point where we can repair the body faster than it deteriorates, meaning we may never have to die from aging.

Aubrey compares the human body to a car. A car may be designed to last only 15 years, but with perfect maintenance, it can keep running for a century or more. The same principle applies to humans: if we maintain and repair our bodies efficiently, there’s no reason we should succumb to aging.

In this episode, we explore what happens once we can rejuvenate the human body by 20 years and what that means for those alive today. Curing cancer could take as little as 2 to 2.5 years, and eliminating heart disease might only require 3 to 4 years. But beyond simply extending lifespan, how do we ensure that longevity is matched by quality of life?

We also dive into the case of Bryan Johnson, the biohacker on a mission to live past 150 years. While his ultra-optimized Blueprint lifestyle is slowing his aging, Aubrey de Grey explains why Bryan Johnson is not Jeanne Calment, the longest-lived human in recorded history. So can Bryan really reach his ambitious goal?

Beyond biology, we discuss the critical funding gap in longevity research, with de Grey estimating that $100 million could significantly accelerate progress toward solving aging. Could advances in Ozempic and Yamanaka Factorsplay a key role in future rejuvenation therapies? And how much impact will AI have on unlocking the secrets of longevity?

If Longevity Escape Velocity is inevitable, what does that mean for the future of humanity? Will people in their 40s and 50s today have a real chance at reaching 150 or beyond? Or are we still too far away from making this a reality?

Join the conversation as we explore the future of aging, longevity, and the quest to live indefinitely.

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Listen on: Apple Podcasts Spotify