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Briefing Document: Glucose Importance for Brain Function Date: October 26, 2023 Subject: Glucose's Role as Primary Brain Fuel Source: Excerpts from "Why we need sugar (glucose)? @Metabolism Made Easy" Main Theme: This document highlights the critical role of glucose as the primary energy source for the brain and the body's mechanisms for maintaining adequate glucose levels. Key Ideas & Facts: Glucose as the Brain's Preferred Fuel: The brain relies heavily on glucose for energy. As stated in the excerpt: "the brain's favorite energy source is glucose". Limited Alternative Fuel Sources: While the brain can utilize ketone bodies, it cannot use fatty acids due to the blood-brain barrier. The document mentions that the brain will only use Ketone bodies when their concentrations reach significantly high levels. Hormonal Regulation of Glucose Levels: The body has intricate mechanisms to maintain sufficient glucose levels. When glucose in the plasma decreases, the brain triggers the release of glucagon, epinephrine, and cortisol, instructing the liver to restore plasma glucose via glycogenolysis and gluconeogenesis. The excerpt says the brain "sends instructions through the hypothalamus and the autonomic nervous system to the pancreas and adrenal glands releasing glucagon epinephrine and cortisol and instructing the liver to restore plasma glucose by glycogenolysis and gluconeogenesis". Implications: This information underscores the importance of maintaining stable glucose levels for optimal brain function and overall health. It highlights the body's complex hormonal response to glucose fluctuations. The brain prioritizes glucose so much that it will orchestrate hormonal processes for restoring adequate levels. LM - generated. Check out the full podcast on why we need glucose: The role of liver gluconeogenesis below: https://youtu.be/PDzJXOsrE4A Also, check out how different tissues metabolize glucose below: https://youtu.be/fGVcxsPwJ9Q