This episode focuses on a randomized, placebo-controlled trial that evaluated the efficacy of infliximab, a tumor necrosis factor (TNF) inhibitor, in alleviating chronic low back pain in patients with Modic type 1 changes (degenerative disc disease with bone marrow edema) identified on magnetic resonance imaging (MRI). The results indicate that TNF blockade is not effective for this condition.

This podcast is based on the publication by Gjefsen E, et al (2024)

and was developed with NotebookLM.

This article presents expert consensus recommendations for diagnosing and treating chronic non-bacterial osteitis (CNO) in adults. A systematic review of existing literature and a multidisciplinary expert panel informed the creation of a standardized disease definition and proposed the term "CNO" to replace previous, less precise terminology. The recommendations cover diagnostic imaging, laboratory testing, and a tiered treatment approach starting with NSAIDs and moving to intravenous bisphosphonates or TNF-α inhibitors as needed. Long-term follow-up and a multidisciplinary care team are emphasized, along with a research agenda to improve understanding and treatment of this rare condition.

This episode of RheumaCast deals the long-anticipated global consensus on MRI protocols for the diagnosis and differential diagnosis of axial spondyloarthritis (axSpA).

Experts from ASAS and SPARTAN, including radiologists and rheumatologists, have developed a comprehensive, standardized imaging protocol designed to maximize diagnostic accuracy and aid early identification of axSpA. The protocol specifies a four-sequence approach focusing on inflammation, structural damage, and bone-cartilage interface visualization—essential elements to ensure consistency in detecting sacroiliitis and distinguishing it from other conditions.

This podcast is based on the publication ⁠Lambert R, et al. Ann Rheum Dis 2024 Aug 6:ard-2024-225882⁠

and is developed with NotebookLM.