『Hurthle Cell Carcinoma: Rare Thyroid Cancer Explained & Managed』のカバーアート

Hurthle Cell Carcinoma: Rare Thyroid Cancer Explained & Managed

Hurthle Cell Carcinoma: Rare Thyroid Cancer Explained & Managed

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Join us for a detailed exploration of Hurthle Cell Carcinoma (HCC)—a rare but aggressive thyroid cancer. In this episode, we cover:

  • 🔬 The unique biology: Hurthle cells (oxyphilic cells), packed with mitochondria, and how they differ from other thyroid cancers
  • 🧩 Diagnostic challenges: why fine-needle biopsies often fall short and why surgery is usually needed
  • 🏷 Tumor classification: minimally invasive, angioinvasive, and widely invasive—and how each affects prognosis
  • 🔬 Cutting-edge genetics: mitochondrial mutations, chromosomal loss/near-haploidy, and why drivers like BRAF or RAS are uncommon
  • 🏥 Treatment essentials: surgery (lobectomy vs. total thyroidectomy), the debated role of radioactive iodine (RAI), and the importance of an expert surgeon
  • 💊 Systemic therapy in advanced cases: targeted kinase inhibitors, mTOR inhibitors, clinical trials, and real-world examples
  • 🩺 Follow-up strategy: ultrasound, thyroglobulin monitoring, TSH suppression, imaging (CT/PET/MRI), and multidisciplinary care

Whether you’re newly diagnosed, in treatment, or a survivor, this guide will help you feel empowered and informed.

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