This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright unpack the latest breakthroughs in metabolic medications and why individual biology requires personalized treatment.

Dr. Cooper explains how modern therapies for metabolic dysfunction go far beyond the old “one pill fixes all” approach. Discover how hormone-based medications like GLP-1 agonists are changing obesity and diabetes care, why medication response can differ drastically between individuals, and what the future holds for tailored metabolic treatments.

You’ll come away with a clearer understanding of why effective weight management isn’t just about diet or willpower—it’s about precision medicine.

Key Takeaways:

• Metabolic dysfunction is a complex, multi-hormonal disease; no single medication will work for everyone.
• New therapies, including dual and triple hormone agonists (like GLP-1, GIP, and amylin analogs), offer synergistic and individualized effects.
• Clinical observation shows that increasing doses or the “latest” medication doesn’t guarantee better results—some people may even get worse on high doses.
• Lab markers (like ghrelin and leptin) could help personalize treatment, but cost and availability limit widespread testing.
• Concerns about muscle loss with GLP-1 drugs are common, but risk mostly depends on nutrition and muscle mass at baseline.
• Accessibility and cost remain barriers; new small-molecule drugs may improve affordability in the near future.

Personal Stories & Practical Advice:

• Andrea relates how understanding her true metabolic issues, rather than just dieting, led to sustainable health changes.
• Dr. Cooper describes her clinic’s approach to measuring body composition and tracking lean mass to avoid unwanted muscle loss.
• Listeners are encouraged to work with knowledgeable providers, beware of “one size fits all” narratives, and stay hopeful as newer, more effective treatments emerge.

Resources from the episode:

• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org or dr.c@fatsciencepodcast.com.

Fat Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright revisit the critical topic of endocrine disruptors—chemicals in our environment that interfere with hormones and impact metabolism, weight, and overall health.

Dr. Cooper breaks down how everyday exposures to substances like phthalates, BPA, and others can have generational effects on metabolic pathways and disease risk. The episode highlights the link between these chemicals and the rising rates of obesity, diabetes, and even cancer, while offering practical steps for minimizing exposure in daily life.

Key Takeaways:

• Endocrine disruptors are chemicals found not only in food but in everyday items such as furniture, makeup, plastics, and baby products, making exposure widespread and difficult to avoid.
• These chemicals can mimic or block hormones, disrupting critical metabolic and developmental processes, with effects that may pass to future generations.
• Regulatory oversight in the U.S. is decreasing, with significant EPA budget cuts threatening existing screening and cleanup programs targeting endocrine-disrupting chemicals.
• Air quality improvements, especially through HEPA filtration, and making informed choices during preconception, pregnancy, and early childhood, can help reduce exposure.
• Consumer awareness, advocacy, and using resources like the Environmental Working Group (EWG) app are key strategies for individuals seeking to lower risk.

Personal Stories & Practical Advice:

• Andrea shares the everyday struggle to find safe, affordable alternatives and the surprise of seeing improvements in metabolic hormone levels after changing air filters and reducing workplace exposures.
• Dr. Cooper discusses strategies to minimize risk during critical windows such as preconception and pregnancy, and emphasizes the power of informed consumer choices in driving safer product development.

Resources from the episode:

• Environmental Working Group (EWG) resources and app for product safety ratings
• U.S. EPA Endocrine Disruptor Screening Program (EDSP)
• PubMed for scientific research on specific chemicals (BPA, phthalates, PFAS)
• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org or dr.c@fatsciencepodcast.com.

Fat Science is supported by the non-profit Diabesity Institute, which aims to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/

This week on Fat Science, Dr. Emily Cooper, Andrea Taylor, and Mark Wright tackle the frustrations of navigating the American healthcare system—especially when it comes to treating metabolic dysfunction, diabetes, and obesity. Mark vents about insurance obstacles, while Dr. Cooper breaks down how short-term thinking, excessive profit layers and lack of preventive care put patient health at risk.

Andrea and Dr. Cooper share personal stories and expertise about the high cost and complexity of accessing vital medications. Together, they explore how incentives, policies, and profit motives harm patient outcomes and propose ideas for a system that truly values health over profits.

Key Takeaways:

• The U.S. healthcare system appears to prioritize short-term profits over long-term health, making it hard for patients to access necessary preventive treatments.
• Insurance companies create barriers to care by denying medications until a patient’s condition worsens, favoring “sick care” over prevention.
• The cost of medications in the U.S. is often exponentially higher than in other countries due to lack of price negotiation and excessive middlemen.
• Access to essential drugs often depends on your employer, state, or industry, creating inequities for those outside favored sectors.
• Real cost savings—and better outcomes—come from investing in prevention and allowing providers and patients to make informed decisions without interference.

Personal Stories & Practical Advice:

• Mark and Andrea describe fights with insurance for medication access, including resorting to Canadian pharmacies and out-of-pocket payments.
• Dr. Cooper explains how prevention in her clinic has reduced heart attacks, strokes, and new cases of diabetes among her high-risk patients.

Resources:

• Connect with Dr. Emily Cooper on LinkedIn.
• Connect with Mark Wright on LinkedIn.
• Connect with Andrea Taylor on Instagram.

Fat Science is a podcast on a mission to explain where our fat really comes from and why it won’t go and stay away. We are committed to creating a world where people are empowered with accurate information about metabolism and recognize that fat isn’t a failure. This podcast is for informational purposes only and is not intended to replace professional medical advice.

If you have a question for Dr. Cooper, a show idea, feedback, or just want to connect, email us at info@diabesityinstitute.org or dr.c@fatsciencepodcast.com.

Science is supported by the non-profit Diabesity Institute which is on a mission to increase access to effective, science-based medical care for those suffering from or at risk for diabesity. https://diabesityresearchfoundation.org/