Stop stressing over every health detail & start living! My FREE 'Necessary Nine' PDF cuts through the noise, giving you the essential things you need for a healthy life.
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What if a single blood test could reveal a hidden, lifelong risk for heart disease that affects one in five people? This risk factor, Lipoprotein(a), is almost entirely determined by your genes and doesn't improve with diet or exercise. In this episode, I break down everything you need to know about Lp(a) and why asking your doctor for this simple, once-in-a-lifetime test could be a game-changer for your health.

CHAPTERS:
00:00 - Introduction
00:44 - What is Lp(a)?
01:30 - The Genetics of Lp(a)
02:27 - 4: Kringle Repeats
03:20 - 5: Epidemiology
04:06 - 6: Global Impact of Lp(a)
04:50 - 7: Why It Actually Causes Increased Risk
05:50 - 8: Atherogenic Pathway
06:31 - 9: Lp(a) and Plaque Stability
07:22 - 10: Pro Inflammatory Pathway
07:57 - 11: Local Inflammation Doesn’t Always Mean Systemic Inflammation
09:03 - 12: Pro Thrombotic Pathway
10:04 - 13: Clinlical Manifestations
10:48 - 14: Screening Recommendations
11:37 - 15: Measuring Lp(a)
13:20 - 16: Defining High Risk Lp(a)
14:32 - 17: Current Management Principles
15:11 - 18: Lowering LDL
17:08 - 19: Statins, Ezetimibe, and Bempedoic Acid
18:25 - 20: PCSK9i and Omega 3’s
19:31 - 21: Therapies to Avoid
20:39 - 22: RNA Based Treatments
21:17 - 23: Antisense Oligonucleotides- Pelacarsen
22:00 - 24: siRNAs- Olpasiran
22:50 - 25: Muvalaplin- An Oral RNA Option
23:28 - 26: Lp(a)/Diabetes Paradox
24:17 - 27: High Risk Populations
25:18 - 28: Key Unanswered Questions
25:53 - 29: Key Takeaways
26:36 - 30: The Future

SELECTED REFERENCES:
https://doi.org/10.3390/ph18050753
https://doi.org/10.1016/j.jacl.2024.03.001
https://doi.org/10.37532/1755-5310.2023.15(S16).395
https://doi.org/10.1161/ATV.0000000000000147
https://doi.org/10.1016/j.ajpc.2024.100651

*Disclaimer* This podcast is for entertainment, education, and informational purposes only. The topics discussed should not solely be used to diagnose, treat , or prevent any condition. The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate. Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.

Could one of the most effective ways to boost survival after a colon cancer diagnosis be exercise? In this episode, I dive deep into the groundbreaking CHALLENGE Trial, a landmark study that explored how a structured exercise program impacts survival rates for colon cancer patients. We'll break down the study's surprising results, including a 28% relative reduction in disease-free survival events and a 37% relative reduction in the risk of death, and discuss what this could mean for the future of cancer care.

Want a checklist to know the most important areas of health you need to take care of?
Click Here: https://www.jrennickemd.com/necessaryninepdf

CHAPTERS:
00:00 - Intro
00:34 - Old Evidence
01:40 - CHALLENGE Trial Intro
02:51 - Population, Invervention, Comparators, Outcomes
04:30 - Healthier Survivor Problem
05:22 - No True “Control” Group
06:55 - Main Results
08:08 - Fitness Outcomes
10:01 - Safety and Side Effects
11:07 - What Explains These Results?
12:03 - Comparing These Results With Older Results
13:27 - New Standard of Care?
15:03 - Future Areas of Research
16:11 - My Takeaways
17:50 - Outro

SELECTED REFERENCES:
https://www.nejm.org/doi/full/10.1056/NEJMoa2502760

*Disclaimer* This podcast is for entertainment, education, and informational purposes only. The topics discussed should not solely be used to diagnose, treat , or prevent any condition. The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate. Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.

colon cancer, exercise, cancer survival, CHALLENGE Trial, oncology, cancer research, disease-free survival, structured exercise program, physical activity, cancer treatment, cancer care, evidence-based medicine

In this podcast, I break down the most effective supplements to optimize your recovery, separating the science from the hype. We'll dive into the foundational pillars of recovery and then take a deep look at everything from protein and carbs to creatine, HMB, tart cherry juice, and more, so you can make informed decisions to support your training.

Sign up for my free newsletter to receive analysis, reviews, and my interpretations of the most recent research to help you stay active for life.

Click Here: https://www.jrennickemd.com

CHAPTERS:

00:00 - Intro

00:35 - Recovery Pillars

03:43 - Protein

05:39 - Whey Protein

07:52 - Casein Protein

09:28 - Plant Protein and Protein Blends

11:57 - Carbohydrates

15:20 - Protein and Carbs Together

16:57 - Creatine

20:08 - HMB

22:07 - Tart Cherry Juice

24:02 - Omega 3’s

25:56 - Magnesium

27:22 - BCAAs

30:20 - L-Glutamine

31:42 - Tiers of Recovery

35:19 - Takeaways

37:25 - Outro

SELECTED REFERENCES:

https://pmc.ncbi.nlm.nih.gov/articles/PMC5852829/

https://pmc.ncbi.nlm.nih.gov/articles/PMC8228369/

https://pmc.ncbi.nlm.nih.gov/articles/PMC9306613/

https://pmc.ncbi.nlm.nih.gov/articles/PMC11918606/

https://pmc.ncbi.nlm.nih.gov/articles/PMC8565244/

Disclaimer

This podcast is for entertainment, education, and informational purposes only. The topics discussed should not solely be used to diagnose, treat , or prevent any condition. The information presented here was created with an evidence based approach, but you please keep in mind that science is always changing and at the time of listening to this there may some new data that makes this information incomplete or inaccurate. Always seek the advice of your personal physician or qualified health care provider for questions regarding any medical condition.