Tess Strebel can’t recognize her own face. She can’t recognize her home. Her bedroom is unfamiliar. And she can’t remember the handsome stranger lying next to her in bed. A stranger who claims he’s her husband. Tess reads a letter in her own handwriting, composed during a rare lucid day, explaining her life as it now exists: she was in a terrible car accident one year ago. Every morning, she wakes up unable to remember most of the last decade. Including her own wedding.

There are only three things in this world that are certain: death, taxes, and babies. Nobody knows this truth better than Emily McCoy, a third year resident working in Baby City, the affectionate nickname for the busy Labor and Delivery unit at a New York City hospital. On a typical day in Baby City, Emily delivers more babies than the number of hours of sleep she manages to squeeze in that night. And definitely more than the number of dates she's been on since she started her training in OB/GYN two years earlier.

Blake Porter is riding high, until he's not. Fired abruptly from his job as a VP of marketing and unable to make the mortgage payments on the new brownstone he shares with his fiancée, he's desperate to make ends meet. Enter Whitney. Beautiful, charming, down-to-earth, and looking for a room to rent. She's exactly what Blake's looking for. Or is she? Because something isn't quite right. The neighbors start treating Blake differently. The smell of decay permeates his home, no matter how hard he scrubs. Strange noises jar him awake in the middle of the night.

Joanne knows how lucky she is—Richard is a wonderful husband, Evie is the most gorgeous baby girl, they live in a beautiful house—life couldn't be better. But then Richard's twenty-year-old daughter Chloe turns up. Chloe hasn’t spoken to her father since the day he married Joanne two years ago. But with the arrival of her baby sister Evie, Chloe wants to make peace. Richard is delighted, and since Joanne is struggling with the new baby, he suggests Chloe could move in and help.

Medical student Amy Brenner is spending the night on a locked psychiatric ward. Amy has been dreading her evening working on Ward D, the hospital’s inpatient mental health unit. There are very specific reasons why she never wanted to do this required overnight rotation. Reasons nobody can ever find out. And as the hours tick by, Amy grows increasingly convinced something terrible is happening within these tightly secured walls.

Erika Cass has a perfect family and a perfect life. Until the evening when two detectives show up at her front door. A high school girl has vanished from Erika's quiet suburban neighborhood. The police suspect the worst - murder. And Erika's teenage son, Liam, was the last person to see the girl alive. Erika has always sensed something dark and disturbed in her seemingly perfect older child. She wants to believe he's innocent, but as the evidence mounts, she can't deny the truth - Liam may have done the unthinkable.

Abby wants a baby more than anything. But after years of failed infertility treatments and adoptions that have fallen through, it seems like motherhood is not in her future. That is, until her personal assistant Monica makes a generous offer that will make all of Abby's dreams come true. But it turns out Monica isn't who she says she is. The woman now carrying Abby's child has an unspeakable secret. And she will stop at nothing to get what she wants.

Sydney Shaw, like every single woman in New York, has terrible luck with dating. She’s seen it all: men who lie in their dating profile, men who stick her with the dinner bill, and worst of all, men who can't shut up about their mothers. But finally, she hits the jackpot. Her new boyfriend is utterly perfect. He's charming, handsome, and works as a doctor at a local hospital. Sydney is swept off her feet. Then the brutal murder of a young woman—the latest in a string of deaths across the coast—confounds police. The primary suspect? A mystery man who dates his victims before he kills them.

A night spent sleeping on dirt and leaves is not how Claire Matchett expected to spend her vacation. She thought this would be a break. A week of hiking and hot tubs with two other couple friends. Then Claire’s minivan breaks down on a lonely dirt road. With no cell reception, the group has no choice but to hike the rest of the way to their hotel. But it turns out the woods aren’t as easy to navigate as they thought. Hours later, they are lost. Hopelessly lost. And as they navigate deeper into the woods, the members of their party are struck down mysteriously one by one.

While eleven-year-old Nora Davis was up in her bedroom doing homework, she had no idea her father was killing women in the basement. Until the day the police arrived at their front door. Decades later, Nora's father is spending his life behind bars, and Nora is a successful surgeon with a quiet, solitary existence. Nobody knows her father was a notorious serial killer. And she intends to keep it that way. `Then Nora discovers one of her young female patients has been murdered. In the same unique and horrific manner that her father used to kill his victims.