E9 | 12 min | Latest | Publication Source

• Podcast based on: Clay R, Li K, Jin L. Metabolic Signaling in the Tumor Microenvironment. Cancers. 2025; 17(1):155. https://doi.org/10.3390/cancers17010155 Type: Review | Publication date: Jan 6, 2025
• Summary: This review article examines metabolic signalling within the tumour microenvironment (TME), focusing on how cancer cells reprogram their metabolism to promote growth and suppress anti-tumour immunity. It explores the roles of key metabolites, such as lactate, glutamine, and adenosine, in intercellular communication and the creation of a hostile TME. The article details how these metabolites affect various cell types, including immune cells and stromal cells, influencing their function and contributing to cancer progression. Finally, it discusses potential therapeutic strategies targeting these metabolic pathways to improve cancer treatment outcomes.
• Keywords: cancer metabolism; tumor microenvironment; immune response; oncometabolite

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